Iles R K, Wathen N C, Sharma K B, Campbell J, Grudzinskas J G, Chard T
Joint Academic Department of Reproductive Physiology, St Bartholomew's Hospital Medical College, West Smithfield, London, UK.
Placenta. 1994 Oct;15(7):693-9. doi: 10.1016/0143-4004(94)90031-0.
First trimester maternal serum levels of pregnancy-associated plasma protein A(PAPP-P) are reduced in women with a Down's syndrome pregnancy. We have examined the concentration of this molecule in the amniotic (AF) and extra-embryonic coelomic (EECF) fluids surrounding the developing fetus. Maternal serum levels of PAPP-A were elevated in all samples and steadily rose from a median of 480 mIU/1 at 8 weeks to a median of 6375 mIU/1 at 14 weeks gestation. Levels of PAPP-A were low in EECF and undetectable in the AF until 14 weeks gestation. This pattern of distribution is in contrast to that of most other trophoblast-associated antigens. This may reflect PAPP-A physiology and its specific production by the syncytiotrophoblast.
怀有唐氏综合征胎儿的孕妇，其孕早期母体血清中妊娠相关血浆蛋白A（PAPP - A）水平降低。我们检测了发育中胎儿周围羊水（AF）和胚外体腔液（EECF）中该分子的浓度。所有样本中母体血清PAPP - A水平均升高，且从妊娠8周时的中位数480 mIU/1稳步升至妊娠14周时的中位数6375 mIU/1。EECF中PAPP - A水平较低，在妊娠14周之前羊水中检测不到。这种分布模式与大多数其他滋养层相关抗原的分布模式不同。这可能反映了PAPP - A的生理学特性及其由合体滋养层的特异性产生。
