U-90152和U-75875在人脑细胞培养物中的抗人类免疫缺陷病毒1型活性。
Anti-human immunodeficiency virus type 1 activities of U-90152 and U-75875 in human brain cell cultures.
作者信息
Peterson P K, Gekker G, Hu S, Chao C C
机构信息
Department of Medicine, Hennepin County Medical Center, Minneapolis, MN 55415.
出版信息
Antimicrob Agents Chemother. 1994 Oct;38(10):2465-8. doi: 10.1128/AAC.38.10.2465.
Abstract
Antiviral activities of the reverse transcriptase inhibitors U-90152 and 3'-azido-2',3'-dideoxythymidine and the protease inhibitor U-75875 were compared in two culture models of human immunodeficiency virus type 1 brain infection. In a model involving acutely infected microglial cells, U-90152 was the most active, whereas in a model using chronically infected promonocytes, U-75875 was the most active.
摘要
在人类免疫缺陷病毒1型脑感染的两种培养模型中，比较了逆转录酶抑制剂U - 90152和3'-叠氮-2',3'-双脱氧胸苷以及蛋白酶抑制剂U - 75875的抗病毒活性。在一个涉及急性感染小胶质细胞的模型中，U - 90152活性最高，而在一个使用慢性感染原单核细胞的模型中，U - 75875活性最高。
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