磷酸吡哆醛对体外gp120-CD4相互作用及1型人类免疫缺陷病毒感染的抑制作用
Inhibition of gp120-CD4 interaction and human immunodeficiency virus type 1 infection in vitro by pyridoxal 5'-phosphate.
作者信息
Guo L, Heinzinger N K, Stevenson M, Schopfer L M, Salhany J M
机构信息
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198-5120.
出版信息
Antimicrob Agents Chemother. 1994 Oct;38(10):2483-7. doi: 10.1128/AAC.38.10.2483.
Abstract
Pyridoxal 5'-phosphate and related compounds were tested for their ability to inhibit gp120-CD4 interaction and human immunodeficiency virus infection in vitro. The results show that pyridoxal 5'-phosphate is a unique CD4 antagonist whose antiviral potency derives from the presence of both lysine-reactive and anionic substituents.
摘要
对磷酸吡哆醛及相关化合物进行了体外抑制 gp120-CD4 相互作用和人类免疫缺陷病毒感染能力的测试。结果表明，磷酸吡哆醛是一种独特的 CD4 拮抗剂，其抗病毒效力源于赖氨酸反应性和阴离子取代基的同时存在。
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