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磷酸吡哆醛对体外gp120-CD4相互作用及1型人类免疫缺陷病毒感染的抑制作用

Inhibition of gp120-CD4 interaction and human immunodeficiency virus type 1 infection in vitro by pyridoxal 5'-phosphate.

作者信息

Guo L, Heinzinger N K, Stevenson M, Schopfer L M, Salhany J M

机构信息

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198-5120.

出版信息

Antimicrob Agents Chemother. 1994 Oct;38(10):2483-7. doi: 10.1128/AAC.38.10.2483.

DOI:10.1128/AAC.38.10.2483
PMID:7530934
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC284769/
Abstract

Pyridoxal 5'-phosphate and related compounds were tested for their ability to inhibit gp120-CD4 interaction and human immunodeficiency virus infection in vitro. The results show that pyridoxal 5'-phosphate is a unique CD4 antagonist whose antiviral potency derives from the presence of both lysine-reactive and anionic substituents.

摘要

对磷酸吡哆醛及相关化合物进行了体外抑制 gp120-CD4 相互作用和人类免疫缺陷病毒感染能力的测试。结果表明，磷酸吡哆醛是一种独特的 CD4 拮抗剂，其抗病毒效力源于赖氨酸反应性和阴离子取代基的同时存在。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c743/284769/2776ee9ffb63/aac00374-0255-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c743/284769/2776ee9ffb63/aac00374-0255-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c743/284769/2776ee9ffb63/aac00374-0255-a.jpg

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本文引用的文献

1
Pyridoxal 5'-phosphate binds specifically to soluble CD4 protein, the HIV-1 receptor. Implications for AIDS therapy.磷酸吡哆醛特异性结合可溶性CD4蛋白，即HIV-1受体。对艾滋病治疗的启示。
J Biol Chem. 1993 Apr 15;268(11):7643-5.
2
Association of integrase, matrix, and reverse transcriptase antigens of human immunodeficiency virus type 1 with viral nucleic acids following acute infection.1型人类免疫缺陷病毒整合酶、基质蛋白和逆转录酶抗原与急性感染后病毒核酸的关联
Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):6125-9. doi: 10.1073/pnas.90.13.6125.
3
The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus.
靶向CD4的gp120结合域的小分子1型人类免疫缺陷病毒进入抑制剂的发现。
J Virol. 2005 May;79(10):6122-33. doi: 10.1128/JVI.79.10.6122-6133.2005.
4
Antiviral therapy for human immunodeficiency virus infections.人类免疫缺陷病毒感染的抗病毒治疗。
Clin Microbiol Rev. 1995 Apr;8(2):200-39. doi: 10.1128/CMR.8.2.200.
CD4（T4）抗原是艾滋病逆转录病毒受体的重要组成部分。
Nature. 1984;312(5996):763-7. doi: 10.1038/312763a0.
4
T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV.T淋巴细胞T4分子作为人类逆转录病毒LAV的受体。
Nature. 1984;312(5996):767-8. doi: 10.1038/312767a0.
5
Fluorescence quantum yield measurements: vitamin B6 compounds.荧光量子产率测量：维生素B6化合物。
Science. 1965 Dec 17;150(3703):1593-5. doi: 10.1126/science.150.3703.1593.
6
A soluble form of CD4 (T4) protein inhibits AIDS virus infection.可溶性形式的CD4（T4）蛋白可抑制艾滋病病毒感染。
Nature. 1988 Jan 7;331(6151):82-4. doi: 10.1038/331082a0.
7
The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain.T4基因编码艾滋病病毒受体，并在免疫系统和大脑中表达。
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8
Biological and biochemical characterization of a cloned Leu-3- cell surviving infection with the acquired immune deficiency syndrome retrovirus.一株感染获得性免疫缺陷综合征逆转录病毒后存活的克隆化Leu-3-细胞的生物学及生化特性
J Exp Med. 1986 Jul 1;164(1):280-90. doi: 10.1084/jem.164.1.280.
9
Designing CD4 immunoadhesins for AIDS therapy.设计用于艾滋病治疗的CD4免疫粘附素。
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J Biol Chem. 1989 May 25;264(15):8746-52.