Ruderman E M, Weinblatt M E, Thurmond L M, Pinkus G S, Gravallese E M
Brigham and Women's Hospital, Boston, Massachusetts.
Arthritis Rheum. 1995 Feb;38(2):254-8. doi: 10.1002/art.1780380215.
Therapeutic trials in rheumatoid arthritis with the monoclonal antibody Campath-1H have demonstrated recurrent clinical synovitis in some patients, despite profound depletion of circulating lymphocytes. This study was undertaken to examine the cellular infiltrates in synovial tissue at a time of persistent peripheral lymphopenia.
Immunohistochemical staining of synovial tissue and peripheral blood lymphocyte phenotyping.
Synovial tissues from 2 patients with recurrent synovitis after Campath-1H therapy contained significant T lymphocytic infiltrates at a time when circulating T lymphocytes were markedly depleted.
These results demonstrate that peripheral blood analysis may not accurately reflect the synovial tissue response to monoclonal antibody therapy.
使用单克隆抗体Campath-1H治疗类风湿关节炎的试验表明，尽管循环淋巴细胞显著减少，但部分患者仍会反复出现临床滑膜炎。本研究旨在检查外周淋巴细胞持续减少时滑膜组织中的细胞浸润情况。
滑膜组织的免疫组织化学染色及外周血淋巴细胞表型分析。
两名接受Campath-1H治疗后出现反复滑膜炎的患者，其滑膜组织在循环T淋巴细胞明显减少时仍含有大量T淋巴细胞浸润。
这些结果表明，外周血分析可能无法准确反映滑膜组织对单克隆抗体治疗的反应。
