Suppr超能文献

适应在RD细胞中生长的柯萨奇病毒B3与衰变加速因子(CD55)结合。

Coxsackievirus B3 adapted to growth in RD cells binds to decay-accelerating factor (CD55).

作者信息

Bergelson J M, Mohanty J G, Crowell R L, St John N F, Lublin D M, Finberg R W

机构信息

Laboratory of Infectious Diseases, Dana-Farber Cancer Institute, Boston, Massachusetts 02115.

出版信息

J Virol. 1995 Mar;69(3):1903-6. doi: 10.1128/JVI.69.3.1903-1906.1995.

Abstract

A coxsackievirus B3 (CB3) isolate adapted to growth in RD cells shows an alteration in cell tropism as a result of its capacity to bind a 70-kDa cell surface molecule expressed on these cells. We now show that this molecule is the complement regulatory protein, decay-accelerating factor (DAF) (CD55). Anti-DAF antibodies prevented CB3 attachment to the cell surface. Radiolabeled CB3 adapted to growth in RD cells bound to CHO cells transfected with human DAF, whereas CB3 (strain Nancy), the parental strain, did not bind to DAF transfectants. These results indicate that growth of CB3 in RD cells selected for a virus strain that uses DAF for cell surface attachment.

摘要

一株适应在RD细胞中生长的柯萨奇病毒B3(CB3)由于其能够结合这些细胞上表达的一种70 kDa细胞表面分子,从而导致细胞嗜性发生改变。我们现在表明,该分子是补体调节蛋白衰变加速因子(DAF)(CD55)。抗DAF抗体可阻止CB3附着于细胞表面。适应在RD细胞中生长的放射性标记CB3可与转染了人DAF的CHO细胞结合,而亲代菌株CB3(Nancy株)则不与DAF转染细胞结合。这些结果表明,在RD细胞中生长的CB3选择了一种利用DAF进行细胞表面附着的病毒株。

相似文献

引用本文的文献

2
Advance of genetically modified pigs in xeno-transplantation.转基因猪在异种移植中的研究进展。
Front Cell Dev Biol. 2022 Oct 10;10:1033197. doi: 10.3389/fcell.2022.1033197. eCollection 2022.
3
Aspects of the Complement System in New Era of Xenotransplantation.补体系统在新时代异种移植中的作用
Front Immunol. 2022 Apr 14;13:860165. doi: 10.3389/fimmu.2022.860165. eCollection 2022.
4
ACE2 and COVID-19 Susceptibility and Severity.血管紧张素转换酶2与新型冠状病毒肺炎易感性及严重程度
Aging Dis. 2022 Apr 1;13(2):360-372. doi: 10.14336/AD.2021.0805. eCollection 2022 Apr.
5
: A Small but Versatile Species.一个小型但用途广泛的物种。
Microorganisms. 2021 Aug 17;9(8):1758. doi: 10.3390/microorganisms9081758.
8
The Role of Non-coding RNAs in Viral Myocarditis.非编码RNA在病毒性心肌炎中的作用。
Front Cell Infect Microbiol. 2020 Jul 2;10:312. doi: 10.3389/fcimb.2020.00312. eCollection 2020.
9
Enterovirus and Encephalitis.肠道病毒与脑炎
Front Microbiol. 2020 Feb 20;11:261. doi: 10.3389/fmicb.2020.00261. eCollection 2020.
10
Evolutionary and Structural Overview of Human Picornavirus Capsid Antibody Evasion.人肠道病毒衣壳抗体逃逸的进化和结构概述。
Front Cell Infect Microbiol. 2019 Aug 20;9:283. doi: 10.3389/fcimb.2019.00283. eCollection 2019.

本文引用的文献

4
Attempts to purify a second cellular receptor for a coxsackievirus B3 variant, CB3-RD from HeLa cells.
Virus Res. 1993 Sep;29(3):305-20. doi: 10.1016/0168-1702(93)90068-x.
5
Integrins as receptors for virus attachment and cell entry.
Trends Microbiol. 1993 Nov;1(8):287-8. doi: 10.1016/0966-842x(93)90003-a.
10
The enzymatic iodination of the red cell membrane.红细胞膜的酶促碘化作用。
J Cell Biol. 1972 Nov;55(2):390-405. doi: 10.1083/jcb.55.2.390.

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验