Gritsenko V A, Liashenko I E
Zh Mikrobiol Epidemiol Immunobiol. 1994 Aug-Sep;Suppl 1:87-91.
The multiple evaluation of the persistence characteristics, including antilysozyme, anti-interferon and anticomplement activity, as well as other biological properties, such as adhesiveness, colicinogenicity and resistance to antibiotics, was carried out in 173 E. coli strains isolated from water, healthy and sick children. This evaluation revealed that each group of E. coli, depending on the source of its isolation, had its characteristic set of properties (or bioprofiles) to be analyzed, making it different from other bacterial populations. The comparative intergroup analysis showed differences between E. coli isolated from children with pathological conditions (enteric coli-bacteriosis, pyelonephritis) and E. coli isolated from water and feces of healthy children. These differences were manifested by more pronounced persistence characteristics. Dispersion analysis, having confirmed this feature, revealed that the most labile characteristics of E.coli, subject to the influence of ecological conditions, were their markers of persistence and antibiotic resistance. The results of factor analysis made it possible to unite the above mentioned properties which determined, together with adhesiveness, pathogenic potential of these bacteria.
对173株从水、健康儿童和患病儿童中分离出的大肠杆菌菌株进行了多种持久性特征评估，包括抗溶菌酶、抗干扰素和抗补体活性，以及其他生物学特性，如黏附性、产大肠杆菌素能力和抗生素抗性。该评估表明，每组大肠杆菌根据其分离来源，都有其独特的特性集（或生物谱）可供分析，这使其与其他细菌群体有所不同。组间比较分析显示，从患有病理状况的儿童（肠道大肠杆菌病、肾盂肾炎）中分离出的大肠杆菌与从健康儿童的水和粪便中分离出的大肠杆菌之间存在差异。这些差异表现为更明显的持久性特征。方差分析证实了这一特征，结果显示，受生态条件影响，大肠杆菌最不稳定的特征是其持久性和抗生素抗性标记。因子分析结果使我们能够将上述特性与黏附性一起确定这些细菌的致病潜力。
