Gritsenko V A, Liashenko I E, Gordienko L M, Vialokova A A, Bukharin O V
Zh Mikrobiol Epidemiol Immunobiol. 1996 May-Jun(3):80-3.
In 181 E. coli strains isolated from sick children having chronic pyelonephritis and risk factors of its development, as well as from healthy children, the complex of phenotypic signs, and among them bacterial persistence markers (antilysozyme, anticomplementary and "anti-interferon" activity), adhesive capacity, antibiotic resistance and colicinogenicity, were analyzed. The specific bioprofiles of E. coli, the causative agents of pyelonephritis, were established. The most informative biological characteristics of E. coli were determined and used as the basis for the development of the algorithm for differentiating the causative agents of pyelonephritis from transitory and contaminating flora. The effectiveness of the proposed diagnostic algorithm was confirmed by clinical approbation.
对从患有慢性肾盂肾炎及其发展危险因素的患病儿童以及健康儿童中分离出的181株大肠杆菌菌株，分析了其表型特征复合体，其中包括细菌持续性标志物（抗溶菌酶、抗补体和“抗干扰素”活性）、黏附能力、抗生素耐药性和产大肠杆菌素能力。确定了肾盂肾炎病原体大肠杆菌的特定生物谱。确定了大肠杆菌最具信息价值的生物学特征，并将其作为开发区分肾盂肾炎病原体与短暂性和污染性菌群算法的基础。临床验证证实了所提出诊断算法的有效性。
