Teichmann B, Schmidt A
Arch Geschwulstforsch. 1978;48(8):718-21.
0,0-Dimethyl(1-hydroxy-2,2,2-trichlorethyl)phosphonate (Trichlorfon; TCP) was tested for carcinogenic activity in male and female Syrian hamsters (Mesocricetus auratus Waterhouse) by intraperitoneal administration. The period of administration was 90 weeks, when maximum total doses of 204 mg (male) and 206 mg (female) TCP per animal had been injected. The study was terminated at 100 weeks. There was no statistically significant difference, when compared the total tumour incidence, or the incidence of malignant and benign tumours separated, of the groups of treated and control animals. These findings were independent from whether the groups of TCP-injected animals and controls were combined or divided by sex.
通过腹腔注射，对雄性和雌性叙利亚仓鼠（金仓鼠，Mesocricetus auratus Waterhouse）进行0,0-二甲基（1-羟基-2,2,2-三氯乙基）膦酸酯（敌百虫；TCP）致癌活性测试。给药期为90周，每只动物腹腔注射TCP的最大总剂量为雄性204毫克、雌性206毫克。该研究在100周时终止。比较处理组和对照组动物的总肿瘤发生率，或分别比较恶性和良性肿瘤的发生率时，未发现统计学上的显著差异。这些结果与注射TCP的动物组和对照组是按性别合并还是分开无关。
