Zylińska K, Komorowski J, Robak T, Mucha S, Stepień H
Institute of Endocrinology, University School of Medicine, Lódź, Poland.
J Neuroimmunol. 1995 Feb;56(2):187-90. doi: 10.1016/0165-5728(94)00146-f.
The study was performed in order to clarify whether granulocyte-macrophage colony stimulating factor (GM-CSF) and granulocyte colony stimulating factor (G-CSF) affect melatonin production and release. We have found that both factors (GM-CSF at doses of 10.0 and 100.0 micrograms/kg, and G-CSF at doses of 1.0, 10.0, and 100.0 micrograms/kg) stimulate melatonin secretion in rats in vivo. Positive correlations between tested doses of GM-CSF and G-CSF and plasma melatonin levels were observed (P < 0.01). Moreover, GM-CSF at doses of 2.0 and 20.0 ng/ml activated in vitro the pineal gland to melatonin release (P < 0.05) in a dose-dependent manner.
进行这项研究是为了阐明粒细胞巨噬细胞集落刺激因子（GM-CSF）和粒细胞集落刺激因子（G-CSF）是否会影响褪黑素的产生和释放。我们发现，这两种因子（剂量为10.0和100.0微克/千克的GM-CSF，以及剂量为1.0、10.0和100.0微克/千克的G-CSF）在体内均可刺激大鼠褪黑素分泌。观察到GM-CSF和G-CSF的测试剂量与血浆褪黑素水平之间呈正相关（P < 0.01）。此外，剂量为2.0和20.0纳克/毫升的GM-CSF在体外以剂量依赖的方式激活松果体释放褪黑素（P < 0.05）。
