平面脂质双分子层中单个通道的非随机分布。

Non stochastic distribution of single channels in planar lipid bilayers.

作者信息

Krasilnikov O V, Merzliak P G, Yuldasheva L N, Nogueira R A, Rodrigues C G

机构信息

Laboratory of Molecular Physiology, Institute of Physiology and Biophysics, Tashkent, Uzbekistan.

出版信息

Biochim Biophys Acta. 1995 Feb 15;1233(2):105-10. doi: 10.1016/0005-2736(94)00231-d.

DOI:10.1016/0005-2736(94)00231-d

PMID:7532434

Abstract

The selectivity of the planar lipid bilayers modified by two channel-forming proteins (alpha-toxin S. aureus and colicin Ia) was examined. It was established that in all cases the value of zero current potential depended on the amount of open ion channels and increased with the number of channels (from one to about 5-7). These facts point out both the interactions among ion channels and their non stochastic distribution on the membrane surface.

摘要

研究了由两种形成通道的蛋白质（金黄色葡萄球菌α毒素和大肠菌素Ia）修饰的平面脂质双层的选择性。结果表明，在所有情况下，零电流电位的值取决于开放离子通道的数量，并随着通道数量的增加而增加（从一个增加到约5-7个）。这些事实既表明了离子通道之间的相互作用，也表明了它们在膜表面的非随机分布。