Crook M A, Treloar A, Haq M, Tutt P
Department of Clinical Chemistry, Guy's Hospital, London, England, U.K.
Eur J Clin Chem Clin Biochem. 1994 Oct;32(10):745-7. doi: 10.1515/cclm.1994.32.10.745.
Serum total sialic acid has gained recent interest as a cardiovascular risk factor. We measured serum total sialic acid and three acute phase proteins; C-reactive protein, alpha 1-antichymotrypsin and alpha 1-acid glycoprotein in 37 geriatric patients (age 80.1 +/- 7.0 years) and 50 younger subjects (age 40.3 +/- 11.4 years). Serum total sialic acid was higher in the geriatric subjects 2.41 +/- 0.39 mmol/l versus 2.04 +/- 0.35 mmol/l, P < 0.04. Serum alpha 1-acid glycoprotein, alpha 1-antichymotrypsin and C-reactive protein were also elevated in the geriatric patients; serum alpha 1-acid glycoprotein being 1.16 +/- 0.32 g/l versus 0.41 +/- 0.28 g/l, P < 0.0001, serum alpha 1-antichymotrypsin being 0.80 +/- 0.20 g/l versus 0.52 +/- 0.10 g/l, P < 0.0001 and serum C-reactive protein being 9.71 +/- 21.0 mg/l versus 4.73 +/- 1.30 mg/l, P < 0.04. There was a correlation with serum total sialic acid and serum alpha 1-acid glycoprotein and alpha 1-antichymotrypsin in the geriatric subjects and with alpha 1-acid glycoprotein, alpha 1-antichymotrypsin and C-reactive protein in the younger group.
血清总唾液酸作为一种心血管危险因素，近来受到了关注。我们测定了37例老年患者（年龄80.1±7.0岁）和50例年轻受试者（年龄40.3±11.4岁）的血清总唾液酸及三种急性期蛋白，即C反应蛋白、α1-抗糜蛋白酶和α1-酸性糖蛋白。老年受试者的血清总唾液酸较高，为2.41±0.39毫摩尔/升，而年轻受试者为2.04±0.35毫摩尔/升，P<0.04。老年患者的血清α1-酸性糖蛋白、α1-抗糜蛋白酶和C反应蛋白也升高；血清α1-酸性糖蛋白为1.16±0.32克/升，而年轻受试者为0.41±0.28克/升，P<0.0001；血清α1-抗糜蛋白酶为0.80±0.20克/升，而年轻受试者为0.52±0.10克/升，P<0.0001；血清C反应蛋白为9.71±21.0毫克/升，而年轻受试者为4.73±1.30毫克/升，P<0.04。老年受试者中血清总唾液酸与血清α1-酸性糖蛋白和α1-抗糜蛋白酶存在相关性，年轻组中血清总唾液酸与α1-酸性糖蛋白、α1-抗糜蛋白酶和C反应蛋白存在相关性。
