Haq M, Haq S, Tutt P, Crook M
Guy's Hospital, London, UK.
Ann Clin Biochem. 1993 Jul;30 ( Pt 4):383-6. doi: 10.1177/000456329303000406.
Serum total sialic acid (TSA) has gained medical interest, particularly as a cardiovascular risk factor and it has been hypothesized that serum levels relate to serum acute phase proteins, some of which are sialylated. We assayed serum TSA and also lipid associated sialic acid (LASA) in 50 normal individuals (24 male) and 15 subjects (12 male) who had experienced a myocardial infarct. The mean serum TSA in the normal individuals was 2.05 SD 0.38 mmol/L (range 1.16-2.74) and the mean serum LASA was 0.70 SD 0.19 mmol/L (range 0.23-1.03). We also measured five serum acute phase proteins and found a good correlation between these and serum TSA: C-reactive protein, r = 0.52, P < 0.001, alpha-1-antichymotrypsin, r = 0.79, P < 0.0001, alpha-2-macroglobulin, r = 0.38, P < 0.01 and alpha-1-acid glycoprotein, r = 0.32, P < 0.05. A significant correlation between plasma TSA and plasma C-reactive protein (r = 0.47, P < 0.04) and also fibrinogen (r = 0.53, P < 0.04) was noted on day one following the myocardial infarction, whereas a significant correlation between plasma TSA and plasma alpha-1-antichymotrypsin (r = 0.51, P < 0.03) and also plasma alpha-1-acid glycoprotein (r = 0.64, P < 0.05) was found on day two following the infarction. Thus it would seem that serum TSA is at least in part related to some of the acute phase proteins in both healthy individuals and those having had a myocardial infarction.
血清总唾液酸（TSA）已引起医学关注，尤其是作为一种心血管危险因素，并且有人推测血清水平与血清急性期蛋白有关，其中一些急性期蛋白是唾液酸化的。我们对50名正常个体（24名男性）和15名经历过心肌梗死的受试者（12名男性）检测了血清TSA以及脂质相关唾液酸（LASA）。正常个体的平均血清TSA为2.05±0.38 mmol/L（范围1.16 - 2.74），平均血清LASA为0.70±0.19 mmol/L（范围0.23 - 1.03）。我们还测量了五种血清急性期蛋白，发现它们与血清TSA之间存在良好的相关性：C反应蛋白，r = 0.52，P < 0.001；α1抗糜蛋白酶，r = 0.79，P < 0.0001；α2巨球蛋白，r = 0.38，P < 0.01；α1酸性糖蛋白，r = 0.32，P < 0.05。在心肌梗死后第一天，血浆TSA与血浆C反应蛋白（r = 0.47，P < 0.04）以及纤维蛋白原（r = 0.53，P < 0.04）之间存在显著相关性，而在梗死后第二天，血浆TSA与血浆α1抗糜蛋白酶（r = 0.51，P < 0.03）以及血浆α1酸性糖蛋白（r = 0.64，P < 0.05）之间存在显著相关性。因此，似乎血清TSA至少部分与健康个体和心肌梗死患者的一些急性期蛋白有关。
