Crook M A, Tutt P, Simpson H, Pickup J C
Division of Chemical Pathology, United Medical School, Guy's Hospital, London, UK.
Clin Chim Acta. 1993 Oct 15;219(1-2):131-8. doi: 10.1016/0009-8981(93)90204-h.
Serum sialic acid is a risk factor for cardiovascular disease in the general population. Serum total sialic acid concentrations were therefore measured in 20 type 1 diabetic patients and in 20 age- and sex-matched non-diabetic subjects. Serum sialic acid were not significantly different in the type 1 diabetic patients and the normal subjects (2.00 +/- 0.37 vs. 1.98 +/- 0.67 mmol/l), but was significantly correlated with serum total cholesterol (r = 0.55, P < 0.02) and serum triglyceride concentration (r = 0.63, P < 0.01) in the type 1 diabetic patients. There was no relationship of sialic acid levels to age, duration of diabetes, smoking, body mass index, systolic or diastolic blood pressure, plasma glucose, serum fructosamine, or daily insulin dosage. Six of the type 1 diabetic patients with retinopathy had higher total serum sialic acid concentrations than those patients without retinopathy (2.38 +/- 0.33 vs. 1.85 +/- 0.26 mmol/l, P < 0.01). A further study of 16 type 1 and 16 type 2 diabetic patients matched for serum fructosamine and blood glucose concentrations and without tissue complications showed that the serum total sialic acid concentration was significantly higher in the type 2 diabetic patients compared with the type 1 patients (2.32 +/- 0.41 vs. 1.84 +/- 0.24 mmol/l, P < 0.001). Although the serum concentrations of the non-sialylated acute phase protein, C-reactive protein, was higher in type 2 than type 1 diabetes, sialylated acute phase protein levels did not explain differences in serum total sialic acid in diabetes.(ABSTRACT TRUNCATED AT 250 WORDS)
血清唾液酸是普通人群心血管疾病的一个危险因素。因此，对20名1型糖尿病患者以及20名年龄和性别匹配的非糖尿病受试者测定了血清总唾液酸浓度。1型糖尿病患者和正常受试者的血清唾液酸无显著差异（2.00±0.37 vs. 1.98±0.67 mmol/L），但在1型糖尿病患者中，血清唾液酸与血清总胆固醇（r = 0.55，P < 0.02）和血清甘油三酯浓度（r = 0.63，P < 0.01）显著相关。唾液酸水平与年龄、糖尿病病程、吸烟、体重指数、收缩压或舒张压、血糖、血清果糖胺或每日胰岛素剂量均无关联。6名患有视网膜病变的1型糖尿病患者的血清总唾液酸浓度高于无视网膜病变的患者（2.38±0.33 vs. 1.85±0.26 mmol/L，P < 0.01）。另一项对16名1型糖尿病患者和16名2型糖尿病患者的研究，这些患者血清果糖胺和血糖浓度匹配且无组织并发症，结果显示，2型糖尿病患者的血清总唾液酸浓度显著高于1型糖尿病患者（2.32±0.41 vs. 1.84±0.24 mmol/L，P < 0.001）。尽管2型糖尿病患者中非唾液酸化急性期蛋白C反应蛋白的血清浓度高于1型糖尿病患者，但唾液酸化急性期蛋白水平并不能解释糖尿病患者血清总唾液酸的差异。（摘要截选至250词）
