Wang H Y, Wang L, Zhang G Q
Nephrology Institute, Beijing Medical University.
Zhonghua Nei Ke Za Zhi. 1994 Jun;33(6):402-4.
Hepatitis C virus (HCV) infection is one of the important causes of chronic and severe hepatitis in China. In an attempt to understand if there is any relationship between HCV infection and glomerulonephritis (GN), serum samples from 570 GN patients and 100 normal volunteers were screened for anti-HCV antibody (HCV-Ab) with ELISA method. Among the cases with positive HCV-Ab, serum HCV-RNA was tested with nested RT-PCR method. The incidence of serum HCV-Ab was 2 in 100 normal volunteers (2%) and 34 in 570 GN patients (6%). The incidence of positive serum HCV-RNA was 0 in normal volunteers whereas 21 in GN patients. The main clinical manifestation of GN patients with serum positive HCV-Ab was an unique proteinuria with/without nephrotic syndrome or renal failure, whereas the pathologic lesions in GN patients with serum positive HCV-Ab or HCV-RNA consisted of different disease entities. There was no close link between MPGN and active HCV infection. From the data observed, it seems that there is a coincidence between glomerular diseases and HCV infection rather than a matter of cause and consequence.
丙型肝炎病毒（HCV）感染是中国慢性重症肝炎的重要病因之一。为了解HCV感染与肾小球肾炎（GN）之间是否存在关联，采用酶联免疫吸附测定（ELISA）法对570例GN患者和100名正常志愿者的血清样本进行了抗HCV抗体（HCV-Ab）筛查。在HCV-Ab阳性的病例中，采用巢式逆转录-聚合酶链反应（RT-PCR）法检测血清HCV-RNA。正常志愿者中血清HCV-Ab的发生率为100例中有2例（2%），GN患者中为570例中有34例（6%）。正常志愿者血清HCV-RNA阳性率为0，而GN患者为21例。血清HCV-Ab阳性的GN患者的主要临床表现为伴有或不伴有肾病综合征或肾衰竭的独特蛋白尿，而血清HCV-Ab或HCV-RNA阳性的GN患者的病理病变由不同的疾病实体组成。膜增生性肾小球肾炎（MPGN）与活动性HCV感染之间没有密切联系。从观察到的数据来看，似乎肾小球疾病与HCV感染之间是一种巧合，而非因果关系。
