一种泛淋巴细胞单克隆抗体的特性，该抗体可用于区分白血病细胞与正常髓系祖细胞，以及区分单核细胞与巨噬细胞。
Characterization of a pan-lymphocyte monoclonal antibody useful in differentiating leukemic from normal myeloid progenitors and monocytes from macrophages.
作者信息
Nadkarni J S, Chitnis V S, Panse G T, Rao S G, Nadkarni J J
机构信息
Immuno-Biochem. Laboratory, Tata Memorial Hospital, Parel, Bombay, India.
出版信息
Neoplasma. 1994;41(6):319-24.
A monoclonal antibody (McAb) designated 3A2 that recognizes a 51 kDa epitope having surface density of 37 x 10(8) per MOLT-4 cells is described. This epitope appears to be expressed on (i) lymphocytes at all stages of differentiation; (ii) leukemic myeloid progenitors; (iii) peripheral blood monocytes (MO). The epitope is specifically absent from normal myeloid progenitors and macrophages. The McAb may, therefore, be useful in studying myeloid lineage leukemias and, as a marker for monocyte to macrophage (MO + MAC) differentiation.
描述了一种名为3A2的单克隆抗体（McAb），它能识别一个51 kDa的表位，该表位在每MOLT-4细胞上的表面密度为37×10⁸。这个表位似乎在以下细胞上表达：（i）分化各阶段的淋巴细胞；（ii）白血病髓系祖细胞；（iii）外周血单核细胞（MO）。正常髓系祖细胞和巨噬细胞中则特异性缺乏该表位。因此，这种单克隆抗体可能有助于研究髓系白血病，并可作为单核细胞向巨噬细胞（MO + MAC）分化的标志物。
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