某些恶性黑色素瘤细胞是否与髓系单核细胞谱系共享抗原？
Do some malignant melanoma cells share antigens with the myeloid monocyte lineage?
作者信息
Munzarová M, Rejthar A, Mechl Z
机构信息
Research Institute of Clinical and Experimental Oncology, Brno, Czechoslovakia.
出版信息
Neoplasma. 1991;38(4):401-5.
Melanoma cells freshly isolated from 63 advanced primary lesions and 103 metastases were analyzed by staining with monoclonal antibodies MEM 28 directed against a 200 kDa antigen present on all leukocytes and tissue macrophages (CD 45), MEM 18 directed against a monocyte antigen of 53 kDa, anti CD 14--Immunotech, Marseille and 3.9 directed against a 150 kDa antigen expressed on monocytes and to even greater degree on most tissue macrophages (CD 11 c). All antibodies showed variable reactivity with melanoma cells, percentage of positive tumor cells ranged from 0 to 70.
对从63个晚期原发性病灶和103个转移灶中新鲜分离出的黑色素瘤细胞进行分析，使用单克隆抗体进行染色：针对所有白细胞和组织巨噬细胞上存在的一种200 kDa抗原（CD 45）的MEM 28、针对一种53 kDa单核细胞抗原的MEM 18、抗CD 14（免疫技术公司，马赛）以及针对单核细胞上表达且在大多数组织巨噬细胞（CD 11 c）上表达程度更高的一种150 kDa抗原的3.9。所有抗体与黑色素瘤细胞的反应性各不相同，阳性肿瘤细胞百分比范围为0至70。
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