Todd R F, Nadler L M, Schlossman S F
J Immunol. 1981 Apr;126(4):1435-42.
Two antigens (Mo1 and Mo2) present on human peripheral blood monocytes have been defined by lytic IgM monoclonal antibodies. Both antigens are present on greater than 70% of adherent mononuclear cells (predominantly monocytes). Mo1 is expressed by monocytes, granulocytes, and Null cells, but is absent from T and B lymphocytes. Mo2, on the other hand, appears specific for peripheral blood monocytes. Neither antigen is present on Ia-positive B cell lines or on tumor cells from patients with B cell lymphoproliferative malignancies, further excluding the possibility that Mo1 and Mo2 are Ia antigens. Mo1 and Mo2 are, however, present on a significant number of blast cells from patients with monocytic leukemia (both myelomonocytic and pure monocytic variants), but relatively infrequently expressed by cells from patients with acute granulocytic leukemia. These results indicate that Mo1 and Mo2 are unique antigens that may represent distinct stages of late monocyte-granulocyte differentiation.
通过溶细胞性IgM单克隆抗体已确定了人外周血单核细胞上存在的两种抗原（Mo1和Mo2）。两种抗原在超过70%的贴壁单核细胞（主要是单核细胞）上都有表达。Mo1由单核细胞、粒细胞和Null细胞表达，但T和B淋巴细胞上没有。另一方面，Mo2似乎对外周血单核细胞具有特异性。两种抗原在Ia阳性B细胞系或B细胞淋巴增殖性恶性肿瘤患者的肿瘤细胞上均不存在，这进一步排除了Mo1和Mo2是Ia抗原的可能性。然而，Mo1和Mo2在相当数量的单核细胞白血病患者（包括粒单核细胞白血病和纯单核细胞变异型）的原始细胞上存在，但急性粒细胞白血病患者的细胞相对较少表达。这些结果表明，Mo1和Mo2是独特的抗原，可能代表单核细胞 - 粒细胞晚期分化的不同阶段。
