Namba H, Kobayashi S, Iwadate Y, Saegusa T, Sato A, Watanabe Y, Sueyoshi K
Division of Neurosurgery, Chiba Cancer Center Hospital.
Neurol Med Chir (Tokyo). 1994 Dec;34(12):832-5. doi: 10.2176/nmc.34.832.
The brain areas perfused by superselective intra-arterial (i.a.) chemotherapy were assessed using single photon emission computed tomography (SPECT) with technetium-99m-hexamethyl-propyleneamine oxime (99mTc-HMPAO). A superselective catheter was introduced into the anterior, middle, or posterior cerebral artery of patients with malignant glioma for i.a. chemotherapy. 99mTc-HMPAO was subsequently injected via the same catheter used for chemotherapy, and a higher dose of 99mTc-HMPAO was injected intravenously to obtain adequate background brain images. Comparison of the SPECT images with magnetic resonance images could confirm complete perfusion of the tumor tissue. In two patients with malignant glioma, regions of interest were selected in the peritumoral brain area and a reference brain area, and the radioactivity was measured. The concentration of 99mTc-HMPAO was about 50 times higher in tissue perfused by superselective injection into anterior or middle cerebral artery compared to intravenous injection. 99mTc-HMPAO SPECT is readily available in many institutions and the information provided is useful for planning more effective and safe i.a. chemotherapy.
使用锝-99m-六甲基丙烯胺肟（99mTc-HMPAO）单光子发射计算机断层扫描（SPECT）评估经超选择性动脉内（i.a.）化疗灌注的脑区。将超选择性导管插入恶性胶质瘤患者的大脑前动脉、中动脉或后动脉进行动脉内化疗。随后通过用于化疗的同一导管注射99mTc-HMPAO，并静脉注射更高剂量的99mTc-HMPAO以获得足够的脑背景图像。将SPECT图像与磁共振图像进行比较可确认肿瘤组织的完全灌注。在两名恶性胶质瘤患者中，在瘤周脑区和参考脑区选择感兴趣区，并测量放射性。与静脉注射相比，经超选择性注入大脑前动脉或中动脉灌注的组织中99mTc-HMPAO的浓度高出约50倍。99mTc-HMPAO SPECT在许多机构都很容易获得，所提供的信息有助于规划更有效、更安全的动脉内化疗。
