Di Lernia R, Della Valle G, De Barbieri A, Temelcou O, De Carli L
Biochem Exp Biol. 1978;14(2):107-14.
The effect of Peptichemio (PTC) on cellular growth and on macromolecular syntheses was analyzed through the cell cycle of EUE cells. The cell response to the various treatments was measured by determining plating efficiency, growth rates and incorporation of labelled precursors of DNA, RNA and protein syntheses. Three maximum inhibition points were found on cell survival, one corresponding to the early G1, another to the middle S and a last one to the late G2. Parallel experiments of incorporation of labelled precursors of DNA, RNA and proteins revealed an effect only on DNA during the early and middle S phase.
通过EUE细胞的细胞周期分析了胃蛋白酶（PTC）对细胞生长和大分子合成的影响。通过测定接种效率、生长速率以及DNA、RNA和蛋白质合成的标记前体掺入量来衡量细胞对各种处理的反应。在细胞存活方面发现了三个最大抑制点，一个对应于G1早期，另一个对应于S中期，最后一个对应于G2晚期。DNA、RNA和蛋白质标记前体掺入的平行实验表明，仅在S期早期和中期对DNA有影响。
