一种重组甲型H1N1流感病毒在蒙古的骆驼中引发了致命的动物流行病。

A reassortant H1N1 influenza A virus caused fatal epizootics among camels in Mongolia.

作者信息

Yamnikova S S, Mandler J, Bekh-Ochir Z H, Dachtzeren P, Ludwig S, Lvov D K, Scholtissek C

机构信息

Ivanovsky Institute of Virology, Moscow, Russia.

出版信息

Virology. 1993 Dec;197(2):558-63. doi: 10.1006/viro.1993.1629.

DOI:10.1006/viro.1993.1629

PMID:8249279

Abstract

In the autumn of 1979 a severe influenza epizootic started among camels in Mongolia (Lvov et al., 1982; Viprosi Virusol. 27, 401-405.) Between 1980 and 1983 13 independent isolates of H1N1 viruses were obtained from diseased camels, which were virtually indistinguishable from the human A/USSR/90/77 strain by serological means. Two hundred and seventy-one samples of camel sera collected between 1978 and 1983 contained antibodies against the human A/USSR/90/77 isolate. After experimental infection of camels with some of these isolates, the animals developed similar symptoms as those found during natural infection: coughing, bronchitis, fever, discharge from nose and eyes. A genetic sequence analysis revealed that among the eight segments (genes) the PB1, HA, and NA genes were almost identical with allelic genes of the USSR/77 strain, and the PB2, PA, NP, M, and NS genes were almost identical with those of the A/PR/8/34 strain.

摘要

1979年秋，蒙古骆驼中暴发了一场严重的流感 epizootic（此处epizootic可能有误，推测为epizootic，即动物流行病）（Lvov等人，1982年；《病毒学》第27卷，401 - 405页）。1980年至1983年间，从患病骆驼中获得了13株独立的H1N1病毒分离株，通过血清学方法，这些分离株与人类A/USSR/90/77毒株几乎无法区分。1978年至1983年间采集的271份骆驼血清样本中含有针对人类A/USSR/90/77分离株的抗体。用其中一些分离株对骆驼进行实验性感染后，动物出现了与自然感染时相似的症状：咳嗽、支气管炎、发热、鼻眼分泌物。基因序列分析显示，在八个片段（基因）中，PB1、HA和NA基因与苏联/77毒株的等位基因几乎相同，而PB2、PA、NP、M和NS基因与A/PR/8/34毒株的基因几乎相同。