Oldstone M B, Tishon A, Geckeler R, Lewicki H, Whitton J L
Department of Neuropharmacology, Scripps Research Institute, La Jolla, CA 92037.
Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):2752-5. doi: 10.1073/pnas.89.7.2752.
Of nine established murine haplotypes, mice of three types (H-2d, H-2u, and H-2q) possess major histocompatibility complex class I glycoproteins able to present an identical viral peptide for recognition and lysis by virus-specific cytotoxic T lymphocytes. Incorporation of this viral epitope into a recombinant vaccinia vaccine and administration of a single dose protects mice with these three haplotypes from an ordinarily lethal challenge of virus. Hence, a common epitope can exist. The sharing of the ability to bind such epitopes among different MHC haplotypes underscores the feasibility of developing an effective cytotoxic T-lymphocyte vaccine for outbred populations like humans.
在九种已确定的小鼠单倍型中，三种类型（H-2d、H-2u和H-2q）的小鼠拥有主要组织相容性复合体I类糖蛋白，能够呈递相同的病毒肽，以供病毒特异性细胞毒性T淋巴细胞识别和裂解。将这种病毒表位整合到重组痘苗疫苗中并单次给药，可保护具有这三种单倍型的小鼠免受通常致命的病毒攻击。因此，可能存在共同表位。不同MHC单倍型之间具有结合此类表位的能力，这突出了为人类等远交群体开发有效的细胞毒性T淋巴细胞疫苗的可行性。
