Loupart M L, Armour J, Walker R, Adams S, Brammar W, Varley J
ICI/University Joint Laboratory, University of Leicester, United Kingdom.
Genes Chromosomes Cancer. 1995 Jan;12(1):16-23. doi: 10.1002/gcc.2870120104.
In order to characterise the role of chromosome 1 more fully in breast cancer, polymorphic markers mapping along the length of the whole chromosome were used to assess a panel of 71 tumour-lymphocyte pairs for allelic imbalance. Complex patterns of alterations were established that are consistent with cytogenetic data in the literature. Deletion mapping of individuals with loss of heterozygosity identified five independent smallest common regions of deletion, two of which are novel. There are also three discrete regions showing a gain in copy number of one homologue. The two arms of the chromosome may be subject to different events; the short arm primarily undergoes interstitial deletions, whereas the long arm is subject to whole arm events (as both gains and losses) as well as regional deletions.
为了更全面地描述1号染色体在乳腺癌中的作用，使用沿整条染色体长度定位的多态性标记来评估一组71对肿瘤-淋巴细胞对的等位基因失衡情况。建立了与文献中的细胞遗传学数据一致的复杂改变模式。对杂合性缺失个体进行的缺失图谱分析确定了五个独立的最小常见缺失区域，其中两个是新发现的。还有三个离散区域显示一个同源染色体的拷贝数增加。染色体的两条臂可能经历不同的事件；短臂主要发生中间缺失，而长臂则经历整条臂的事件（包括增加和缺失）以及区域缺失。
