Hara Y, Tooyama I, Yasuhara O, Akiyama H, McGeer P L, Handa J, Kimura H
Department of Neurosurgery, Shiga University of Medical Sciences, Otsu, Japan.
Brain Res. 1994 Nov 21;664(1-2):101-7. doi: 10.1016/0006-8993(94)91959-3.
Expression of acidic fibroblast growth factor (aFGF) was studied by immunocytochemistry in the rat brain with or without cerebral infarction. In a model of infarction produced by occlusion of the middle cerebral artery, aFGF-positive staining that was not seen in controls appeared in both neurons and macrophages. Positive neurons were distributed mainly in the periventricular region of the hypothalamus. The neuronal aFGF began to be detectable about 24 h after the occlusion. The staining intensity for such neuronal aFGF increased until about 14 days after the surgery, but decreased gradually and was undetectable after more than 30 days. Positive macrophages first appeared on the 3rd day after the occlusion and were persistently seen up to the 7th day, but were no longer visible after 14 days. The present results suggest that aFGF may be involved in the repair processes following brain infarction.
采用免疫细胞化学方法研究了酸性成纤维细胞生长因子（aFGF）在大鼠脑梗死和未梗死情况下的表达。在大脑中动脉闭塞所致的梗死模型中，对照组未见的aFGF阳性染色出现在神经元和巨噬细胞中。阳性神经元主要分布在下丘脑室周区域。神经元aFGF在闭塞后约24小时开始可检测到。此类神经元aFGF的染色强度在术后约14天前增加，但逐渐降低，30多天后无法检测到。阳性巨噬细胞在闭塞后第3天首次出现，持续至第7天，但14天后不再可见。目前的结果表明，aFGF可能参与脑梗死的修复过程。
