Ishikawa R, Nishikori K, Furukawa S
Department of Molecular Biology, Gifu Pharmaceutical University, Japan.
Neurosci Lett. 1991 Jun 10;127(1):70-2. doi: 10.1016/0304-3940(91)90897-3.
Time-dependent changes in both nerve growth factor (NGF) and acidic fibroblast growth factor (aFGF) levels in the rat brain after cortical cavity lesioning were examined, by using sensitive enzyme immunoassays (EIA) specific for each factor. In the cavity fluid, the NGF level increased rapidly and temporarily with a sharp peak 16 h after lesioning. A relatively high level was sustained during the next 3-6 days. Contrary to NGF, aFGF was first detectable only 10 days after lesioning, and its level increased gradually until 30 days. These results suggest that NGF and aFGF would play some roles for neuronal repair in different ways.
通过使用针对每种因子的灵敏酶免疫测定法（EIA），研究了大鼠大脑皮质腔损伤后神经生长因子（NGF）和酸性成纤维细胞生长因子（aFGF）水平随时间的变化。在腔液中，NGF水平在损伤后16小时迅速且暂时升高，出现一个尖锐的峰值。在接下来的3至6天内维持相对较高的水平。与NGF相反，aFGF在损伤后10天才首次可检测到，其水平逐渐升高直至30天。这些结果表明，NGF和aFGF将以不同方式在神经元修复中发挥某些作用。
