Vandenbunder B, Wernert N, Queva C, Desbiens X, Stehelin D
Laboratoire d'Oncologie Moléculaire, CNRS-URA 1160, Institut Pasteur de Lille, France.
Folia Biol (Praha). 1994;40(5):301-13.
The c-ets1 proto-oncogene encodes a transcription factor that binds a GGAA/T purine rich core DNA sequence. During normal as well as pathological development, the expression of c-ets1 is associated with the occurrence of invasive processes, either in invading cells or in the invaded tissue. Cellular regulatory sequences responsive to the c-Ets1 proteins include a urokinase-type plasminogen activator (u-PA) gene enhancer, the stromelysin-1 and the collagenase-1 gene promoters. Since invasive processes are thought to require the remodeling of the extra-cellular matrix, we investigate the relationships between c-Ets1 and the expression pattern of transcripts encoding these matrix degrading proteases, in embryos and in solid tumors.
c-ets1原癌基因编码一种转录因子，该转录因子可结合富含GGAA/T嘌呤的核心DNA序列。在正常以及病理发育过程中，c-ets1的表达与侵袭过程的发生相关，侵袭过程可发生于侵袭细胞或被侵袭组织中。对c-Ets1蛋白有反应的细胞调控序列包括尿激酶型纤溶酶原激活剂（u-PA）基因增强子、基质溶解素-1和胶原酶-1基因启动子。由于侵袭过程被认为需要细胞外基质的重塑，我们研究了胚胎和实体瘤中c-Ets1与编码这些基质降解蛋白酶的转录本表达模式之间的关系。
