Vandenbunder B, Queva C, Desbiens X, Wernert N, Stehelin D
Laboratoire d'Oncologie Moléculaire, CNRS-URA 1160, Institut Pasteur de Lille, France.
Invasion Metastasis. 1994;14(1-6):198-209.
The protein encoded by the c-ets1 proto-oncogene is a member of a new family of transcription factors. Cellular regulatory sequences responsive to the c-Ets1 proteins include a urokinase-type plasminogen activator (uPA) gene enhancer, the stromelysin 1 and the collagenase 1 gene promoters. During normal as well as pathological development, the expression of c-ets1 is associated with the occurrence of invasive processes, either in invading cells or in the invaded tissue. Since these invasive processes are thought to require the remodeling of the extracellular matrix, we investigate the relationships between c-Ets1 and the expression patterns of transcripts encoding the matrix-degrading proteases uPA, stromelysin 1 and collagenase 1, in embryos and in solid tumors.
c-ets1原癌基因编码的蛋白质是一个新的转录因子家族的成员。对c-Ets1蛋白有反应的细胞调控序列包括尿激酶型纤溶酶原激活剂（uPA）基因增强子、基质溶解素1和胶原酶1基因启动子。在正常以及病理发育过程中，c-ets1的表达与侵袭过程的发生有关，侵袭过程发生在侵袭细胞或被侵袭组织中。由于这些侵袭过程被认为需要细胞外基质的重塑，我们研究了胚胎和实体瘤中c-Ets1与编码基质降解蛋白酶uPA、基质溶解素1和胶原酶1的转录本表达模式之间的关系。
