Vandenbunder B, Wernert N, Stéhelin D
Laboratoire d'Oncologie Moléculaire, CNRS URA 1160, Institut Pasteur de Lille.
Contracept Fertil Sex. 1994 Oct;22(10):656-60.
During their progression, epithelial tumors induce a stromal reaction essential for their development and for metastasis. In situ hybridization studies have revealed that the protooncogene c-ets1 is expressed in endothelial cells at the beginning tumor angiogenesis, and in stromal fibroblasts surrounding invasive tumors. C-ets1 encodes a transcription factor that may activate the transcription of genes encoding collagenase 1, stromelysin 1 and urokinase plasminogen activator, proteases involved in extracellular matrix degradation. A working hypothesis is that c-Ets1 takes part in regulating invasive processes by controlling the transcription of these genes. Experimental evidences that may confirm this hypothesis will be discussed.
上皮肿瘤在进展过程中会引发一种对其发展和转移至关重要的基质反应。原位杂交研究表明，原癌基因c-ets1在肿瘤血管生成初期的内皮细胞以及侵袭性肿瘤周围的基质成纤维细胞中表达。C-ets1编码一种转录因子，该转录因子可能激活编码胶原酶1、基质溶解素1和尿激酶型纤溶酶原激活剂的基因的转录，这些蛋白酶参与细胞外基质的降解。一个可行的假说是，c-Ets1通过控制这些基因的转录参与调节侵袭过程。将讨论可能证实这一假说的实验证据。
