Mozas J, Castilla J A, Jimena P, Gil T, Acebal M, Herruzo A J
Department of Obstetrics and Gynecology, Hospital Virgen de las Nieves, Granada, Spain.
Int J Gynaecol Obstet. 1994 Jan;44(1):53-7. doi: 10.1016/0020-7292(94)90023-x.
To determine the efficiency of different tumor markers (CA-125, carcinoembryonic antigen, CA-15.3, CA-19.9) and insulin-like growth factor I (IGF-I) measurements as a screening procedure for acute pelvic inflammatory disease (PID).
Peripheral blood samples were obtained at the time of laparoscopy from three groups of women: (1) 50 women who underwent laparoscopic tubal ligation and had no evidence of PID (control group); (2) 20 women admitted because of suspected PID, but at laparoscopy or laparotomy had no signs of PID; (3) 20 patients who underwent acute PID diagnosed by laparoscopy. Serum levels of: CA-125, carcinoembryonic antigen, CA-15.3 and CA-19.9, and plasma IGF-I, were measured by radioimmunoassay.
No differences were observed in the levels of CA-15.3, CA-19.9, carcinoembryonic antigen and IGF-I between the three groups studied. Serum levels of CA-125 were significantly higher in patients who had PID. Analysis of receiver operating characteristic curves showed that only CA-125 was useful in diagnosis of acute PID. The cut-off level was 43.7 U/ml for CA-125.
Measurement of serum CA-125 concentrations is recommended as a useful test for acute PID in patients undergoing laparoscopy for pelvic pain.
确定不同肿瘤标志物（CA - 125、癌胚抗原、CA - 15.3、CA - 19.9）及胰岛素样生长因子I（IGF - I）检测作为急性盆腔炎（PID）筛查方法的效率。
在腹腔镜检查时从三组女性中采集外周血样本：（1）50例行腹腔镜输卵管结扎且无PID证据的女性（对照组）；（2）20例因疑似PID入院，但在腹腔镜检查或剖腹手术时无PID体征的女性；（3）20例经腹腔镜检查诊断为急性PID的患者。采用放射免疫分析法检测血清中CA - 125、癌胚抗原、CA - 15.3和CA - 19.9的水平以及血浆IGF - I的水平。
在所研究的三组之间，CA - 15.3、CA - 19.9、癌胚抗原和IGF - I的水平未观察到差异。PID患者的血清CA - 125水平显著更高。受试者工作特征曲线分析表明，只有CA - 125对急性PID的诊断有用。CA - 125的截断水平为43.7 U/ml。
对于因盆腔疼痛接受腹腔镜检查的患者，建议检测血清CA - 125浓度作为急性PID的一项有用检测。
