Hansenne M, Pitchot W, Gonzalez Moreno A, Papart P, Timsit-Berthier M, Ansseau M
Psychiatric Unit, CHU du Sart Tilman, Liège, Belgium.
Electroencephalogr Clin Neurophysiol. 1995 Mar;96(2):194-6. doi: 10.1016/0168-5597(94)00317-8.
The neurobiology of P300 is still a subject of controversy. P300 amplitude appears to be modulated by multiple neurotransmitter systems, especially dopaminergic, noradrenergic as well as cholinergic and GABAergic. In this study, we investigated the relationship between P300 amplitude and catecholaminergic neurotransmission as assessed by the growth hormone (GH) response to clonidine and apomorphine challenges in 20 major depressive patients. Results showed a correlation of P300 amplitude with the apomorphine test (r = 0.54; P = 0.01), but not with the clonidine test (r = 0.22; NS). This study supports a role for dopamine in the neurobiological modulation of P300 amplitude.
P300的神经生物学仍是一个存在争议的课题。P300波幅似乎受到多种神经递质系统的调节，尤其是多巴胺能、去甲肾上腺素能以及胆碱能和γ-氨基丁酸能系统。在本研究中，我们通过20例重度抑郁症患者对可乐定和阿扑吗啡激发试验的生长激素（GH）反应，研究了P300波幅与儿茶酚胺能神经传递之间的关系。结果显示P300波幅与阿扑吗啡试验相关（r = 0.54；P = 0.01），但与可乐定试验无关（r = 0.22；无显著性差异）。本研究支持多巴胺在P300波幅的神经生物学调节中发挥作用。
