Hansenne M, Ansseau M
Psychiatric Unit, CHU du Sart Tilman, Liège, Belgium.
Psychoneuroendocrinology. 1998 Jul;23(5):477-83. doi: 10.1016/s0306-4530(98)00021-3.
In the biosocial model of Cloninger, the three personality dimensions are related to different central neurotransmission systems. In agreement with this model, a recent study (Wiesbeck et al., 1995) showed an association between growth hormone response to apomorphine, an indirect assessment of the dopaminergic system, and novelty seeking score in alcohol-dependent men. In the present study we investigated the same methodology in a sample of major depressive patients. In addition, we assessed the relationship between noradrenergic function and Cloninger's dimensions using the clonidine test, an indirect assessment of the noradrenergic system. Growth hormone responses to apomorphine and clonidine were not associated with novelty seeking, reward dependence or harm avoidance dimension scores. This study therefore does not confirm the results of Wiesbeck et al. (1995), and does not support an association between noradrenergic activity and reward dependence dimension. However, given the complexity of central neurotransmission systems and the limitations of neuroendocrine challenges for the assessment of those processes, this study could not be considered as definitive evidence against the association between personality dimensions and their hypothesized central substrates.
在克隆宁格的生物社会模型中，三种人格维度与不同的中枢神经传递系统相关。与该模型一致的是，最近一项研究（维斯贝克等人，1995年）表明，对阿扑吗啡的生长激素反应（一种对多巴胺能系统的间接评估）与酒精依赖男性的新奇寻求得分之间存在关联。在本研究中，我们在一组重度抑郁症患者样本中采用了相同的方法。此外，我们使用可乐定试验（一种对去甲肾上腺素能系统的间接评估）评估了去甲肾上腺素能功能与克隆宁格维度之间的关系。对阿扑吗啡和可乐定的生长激素反应与新奇寻求、奖赏依赖或回避伤害维度得分均无关联。因此，本研究未证实维斯贝克等人（1995年）的结果，也不支持去甲肾上腺素能活动与奖赏依赖维度之间存在关联。然而，鉴于中枢神经传递系统的复杂性以及神经内分泌激发试验在评估这些过程方面的局限性，本研究不能被视为反对人格维度与其假定的中枢底物之间存在关联的决定性证据。
