Altstiel L D, Lawlor B, Mohs R, Schmeidler J, Dalton A, Mehta P, Davis K
Department of Psychiatry, Mount Sinai School of Medicine, New York, N.Y. 10029, USA.
Dementia. 1995 Jan-Feb;6(1):17-20. doi: 10.1159/000106917.
A portion of Alzheimer's disease (AD) patients have elevated serum levels of the acute phase reactant alpha 1-antichymotrypsin (A1ACT) compared to age-matched controls. We measured serum levels of A1ACT in AD patients, age-matched controls, Down's syndrome patients, and nondemented first-degree relatives of AD patients. Significantly elevated levels of A1ACT were found in both AD patients and first-degree-relatives. In AD patients, serum A1ACT concentrations decreased with increasing severity of cognitive impairment. These results may suggest that inflammatory phenomena may be an early component of AD pathophysiology.
与年龄匹配的对照组相比，一部分阿尔茨海默病（AD）患者血清中的急性期反应物α1-抗糜蛋白酶（A1ACT）水平升高。我们检测了AD患者、年龄匹配的对照组、唐氏综合征患者以及AD患者的非痴呆一级亲属的血清A1ACT水平。结果发现，AD患者及其一级亲属的A1ACT水平均显著升高。在AD患者中，血清A1ACT浓度随认知障碍严重程度的增加而降低。这些结果可能表明，炎症现象可能是AD病理生理学的早期组成部分。
