Atkison P, Joubert G, Barron A, Grant D, Paradis K, Seidman E, Wall W, Rosenberg H, Howard J, Williams S
Children's Hospital of Western Ontario, University of Western Ontario, London, Canada.
Lancet. 1995 Apr 8;345(8954):894-6. doi: 10.1016/s0140-6736(95)90011-x.
Reported side-effects of tacrolimus, a potent immunosuppressive agent, have not included cardiotoxicity. We describe 5 consecutive paediatric transplant recipients (3 small bowel with or without liver and 2 liver) who received tacrolimus. 2 developed congestive heart failure and hypertrophic obstructive cardiomyopathy which resolved after changing to cyclosporin. In the other 3 patients the cardiomyopathy regressed or improved with a lower dose of tacrolimus or after stopping the drug.
强效免疫抑制剂他克莫司已报道的副作用中不包括心脏毒性。我们描述了5例连续接受他克莫司治疗的儿科移植受者（3例小肠移植，伴或不伴肝脏移植，2例肝脏移植）。其中2例出现充血性心力衰竭和肥厚性梗阻性心肌病，在换用环孢素后症状缓解。另外3例患者的心肌病在降低他克莫司剂量或停药后病情缓解或改善。
