Arikuni T, Sako H, Murata A
Department of Anatomy, Nihon University, School of Medicine, Tokyo, Japan.
Neurosci Res. 1994 Nov;21(1):19-39. doi: 10.1016/0168-0102(94)90065-5.
The present study was attempted to study ipsilateral corticocortical connections of the anterior part (area 24) of the cingulate cortex of the macaque monkey by means of wheat germ agglutinin-conjugated peroxidase (WGA-HRP) method. In 2 out of 4 Japanese monkeys (Macaca fuscata) that were injected with WGA-HRP into the anterior part of the cingulate cortex, the sites of injection were successfully localized within the cortical regions corresponding to areas 24a and 24b. The results obtained from these monkeys indicate that areas 24a and 24b in the anterior part of the cingulate cortex are reciprocally connected with the prefrontal, premotor, and motor cortical regions, and also with the medial temporal cortical regions. Areas 24a and 24b were strongly connected with the lateral and medial prefrontal cortices and area 6a beta of the premotor cortex, moderately with the remaining premotor cortex, and weakly with the motor cortex. In the medial temporal cortex, areas 24a and 24b were strongly connected with the prosubiculum, entorhinal cortex (area 28), and perirhinal cortex (areas 35 and 36), and weakly with areas TF and TH of the parahippocampal gyrus, throughout their rostrocaudal extent. In addition, areas 24a and 24b projected to the molecular layer of the CAI subfield of Ammon's horn and the external pyramidal layer of the presubiculum. Our findings suggest that areas 24a and 24b of the anterior cingulate cortex may constitute relays in the reciprocal pathways between the prefrontal cortex and the hippocampal, entorhinal and/or perirhinal cortical regions.
本研究试图通过小麦胚凝集素结合过氧化物酶（WGA-HRP）法研究猕猴扣带回皮质前部（24区）的同侧皮质-皮质连接。在4只日本猕猴（食蟹猴）中，有2只被注射WGA-HRP到扣带回皮质前部，注射部位成功定位在对应于24a和24b区的皮质区域内。从这些猕猴获得的结果表明，扣带回皮质前部的24a和24b区与前额叶、运动前区和运动皮质区域相互连接，也与颞叶内侧皮质区域相互连接。24a和24b区与外侧和内侧前额叶皮质以及运动前皮质的6aβ区有强连接，与其余运动前皮质有中度连接，与运动皮质有弱连接。在颞叶内侧皮质，24a和24b区在其整个前后范围内与前下托、内嗅皮质（28区）和梨状周围皮质（35和36区）有强连接，与海马旁回的TF和TH区有弱连接。此外，24a和24b区投射到海马角CAI亚区的分子层和前下托的外锥体细胞层。我们的研究结果表明，扣带回皮质前部的24a和24b区可能在前额叶皮质与海马、内嗅和/或梨状周围皮质区域之间的相互通路中构成中继站。
