Inhibition is a fundamental concept in the field of depression. It underlies the notion of restraint, and one may recognize in it motor, affective and psychic components. This symptom can be identified from behaviour and actual experiences. Its coexistence with other depression target-symptoms helps to differenciate several clinical forms. It is a preferential symptom, especially at the time of the switch process, for establishing correlations with other parameters, biological and neurophysiological, of depression.