Fagan D G, Lancashire R J, Walker A, Sorahan T
Department of Histopathology, University Hospital, Nottingham.
Arch Dis Child Fetal Neonatal Ed. 1995 Mar;72(2):F111-4. doi: 10.1136/fn.72.2.f111.
Percentage fetal haemoglobins (% HbF) were measured in 7081 newborns at the University Hospital, Nottingham, between 1990 and 1992 to assess the effects of a range of factors, and to determine if there was an association between % HbF at birth and risk of SIDS (sudden infant death syndrome). Data from the obstetric clinical records were analysed by multiple linear regression to establish the major determinants of % HbF. New findings were the identification of maternal smoking, twin pregnancy, ethnic origin, and season of birth as significant determinants. Alcohol use, drug and vitamin intake, and duration of labour were not found to be important. The previously reported correlations between % HbF and sex, gestational age, and birthweight were confirmed, and the relative effects quantified. Overall, the major determinants of an increase in % HbF in neonates are similar to the known antenatal risk factors for sudden infant death syndrome (SIDS).
1990年至1992年间，在诺丁汉大学医院对7081名新生儿进行了胎儿血红蛋白百分比（%HbF）测量，以评估一系列因素的影响，并确定出生时的%HbF与婴儿猝死综合征（SIDS）风险之间是否存在关联。通过多元线性回归分析产科临床记录数据，以确定%HbF的主要决定因素。新发现是确定母亲吸烟、双胎妊娠、种族和出生季节为重要决定因素。未发现饮酒、药物和维生素摄入以及产程时长具有重要意义。先前报道的%HbF与性别、胎龄和出生体重之间的相关性得到证实，并对相对影响进行了量化。总体而言，新生儿%HbF升高的主要决定因素与已知的婴儿猝死综合征（SIDS）产前危险因素相似。
