Malinovskaia V V, Neumoina M V, Budanov S V
Vopr Virusol. 1994 Nov-Dec;39(6):269-72.
Viferon500 suppositories representing a combination of recombinant alpha 2-interferon and membrane-stabilizing agents were used in the treatment of adult patients with acute viral hepatitis B. Changes in interferon status of the blood under the effect of reaferon and viferon500 were studied. Both reaferon and viferon500 suppositories were found to stimulate interferon synthesis in patients with acute viral hepatitis B, their stimulating effect correlating with the positive time course of clinical manifestations of the disease. The results permit us recommend viferon500 for the treatment of viral hepatitis in the early period of the icterus in order to prevent the disease progress. Parameters of the interferon system may serve as an objective criterion for assessment of the treatment efficacy.
维福龙500栓剂是重组α2干扰素与膜稳定剂的组合，用于治疗成年急性乙型病毒性肝炎患者。研究了瑞福隆和维福龙500作用下血液中干扰素状态的变化。发现瑞福隆和维福龙500栓剂均可刺激急性乙型病毒性肝炎患者的干扰素合成，其刺激作用与疾病临床表现的阳性病程相关。这些结果使我们推荐在黄疸早期使用维福龙500治疗病毒性肝炎，以防止疾病进展。干扰素系统参数可作为评估治疗效果的客观标准。
