Reĭzis A R, Malinovskaia V V, Shekhade S, Drondina A K, Nikitina T S, Markarian A S, Nazarenko I V, Mikhaĭlov M I
Pediatriia. 1992(1):60-4.
The authors describe the results of the first experience gained with the use of recombinant alpha 2-interferon in children with acute viral hepatitis B. The drug was administered rectally in combination with antioxidants (tocopherol). The study was carried out by the double blind method with randomization and two control groups (given tocopherol alone or placebo alone). 73 children with acute viral hepatitis B were examined. The therapeutic combination reaferon plus tocopherol was established to favour more rapid elimination of dyspeptic and abdominal phenomena, to shorten the time of the liver and spleen size increase, duration of hyperfermentemia, to provide for an accelerated reduction of HBsAg titers, elimination of HBeAg and seroconversion, to stimulate alpha-interferon production by leukocytes, and to activate the system of mononuclear phagocytes.
作者描述了在急性乙型病毒性肝炎患儿中使用重组α2干扰素的首次经验结果。该药物经直肠给药，并与抗氧化剂（生育酚）联合使用。研究采用双盲法，随机分组，设两个对照组（分别单独给予生育酚或安慰剂）。对73例急性乙型病毒性肝炎患儿进行了检查。已证实治疗组合（瑞芬太尼加生育酚）有利于更快消除消化不良和腹部症状，缩短肝脏和脾脏肿大时间、高酶血症持续时间，加速降低HBsAg滴度，消除HBeAg并实现血清学转换，刺激白细胞产生α干扰素，并激活单核吞噬细胞系统。
