Villa R F, Strada P, Marzatico F, Dagani F
Eur Neurol. 1978;17 Suppl 1:97-112. doi: 10.1159/000115013.
The effect of (-)eburnamonine, papaverine and UDP-glucose intracarotid perfusion has been evaluated in the brain of beagle dogs during various conditions of cerebral damage (hypoxia, hypoxia plus incomplete ischaemia, hypoxia plus complete ischaemia), and after 3, 15 or 30 min of the post-hypoxic recovery and recirculation. The behaviour of fuels (glycogen, glucose), of glycolytic pathway intermediates (glucose-6-phosphate, pyruvate) and end-product (lactate), of the pool of labile phosphates (ATP, ADP, AMP, creatine phosphate) and the energy charge potential of the brain were evaluated in the motor area of the cerebral cortex. The different pharmacological effects of (-)eburnamonine, papaverine and UDP-glucose are discussed with regard to the biochemical changes taking place during the physiopathological conditions tested.
已在比格犬大脑处于各种脑损伤情况（缺氧、缺氧加不完全缺血、缺氧加完全缺血）时，以及在缺氧后恢复和再灌注3、15或30分钟后，评估了(-)埃博纳明、罂粟碱和UDP-葡萄糖颈动脉内灌注的效果。在大脑皮层运动区评估了燃料（糖原、葡萄糖）、糖酵解途径中间产物（6-磷酸葡萄糖、丙酮酸）和终产物（乳酸）、不稳定磷酸盐池（三磷酸腺苷、二磷酸腺苷、一磷酸腺苷、磷酸肌酸）的行为以及大脑的能荷电位。针对在测试的生理病理状况期间发生的生化变化，讨论了(-)埃博纳明、罂粟碱和UDP-葡萄糖的不同药理作用。
