Lasch E E, Livni E, Englander T, el-Massri M, Marcus O, Joshua H
Dev Biol Stand. 1978;41:179-82.
Specific cell mediated immunity to polio antigens was investigated in 22 children suffering from acute paralytic poliomyelitis by the macrophage migration inhibition (MIF) technique. A positive response was observed in 9 out of the 11 patients tested 1-14 days after the onset of the paralysis and in 6 out of the 8 patients tested between 15-90 days. In one case, the response was positive even before paralysis became evident. Out of the 8 patients tested 90-360 days after paralysis, only 3 gave positive results. No response whatsoever could, on the other hand, be observed in the great majority of children tested 1-3 months after having received oral polio vaccine or in healthy adults. These findings demonstrate that in poliomyelitis the specific C.M.I. response can be detected before the circulating antibodies and suggest that possibility of the use of this technique in the early diagnosis of poliomyelitis as well as in the differentiation between this disease and other neurological disorders.
采用巨噬细胞游走抑制（MIF）技术，对22例急性麻痹性脊髓灰质炎患儿针对脊髓灰质炎抗原的特异性细胞介导免疫进行了研究。在瘫痪发作后1 - 14天检测的11例患者中，有9例呈阳性反应；在15 - 90天检测的8例患者中，有6例呈阳性反应。有1例在瘫痪明显之前反应即为阳性。在瘫痪后90 - 360天检测的8例患者中，只有3例结果为阳性。另一方面，在绝大多数口服脊髓灰质炎疫苗后1 - 3个月检测的儿童或健康成人中，未观察到任何反应。这些发现表明，在脊髓灰质炎中，特异性细胞介导免疫反应可在循环抗体出现之前被检测到，并提示该技术在脊髓灰质炎早期诊断以及该疾病与其他神经系统疾病的鉴别诊断中应用的可能性。
