Minatel E, Trovò M G, Forner L, Franchin G, de Paoli A, Roncadin M, Gobitti C, Bassignano G
Radiotherapy Division, Centro di Riferimento Oncologico, Aviano (PN), Italy.
Br J Radiol. 1993 Aug;66(788):699-702. doi: 10.1259/0007-1285-66-788-699.
From January 1980 to May 1991, 28 patients with intraocular metastases were seen at our Institute. Three presented with bilateral metastases and two developed contralateral involvement. Out of the 33 ocular metastases 27 were managed by radiotherapy. The most common primary tumour sites were breast (18/28 patients) and lung (3/28). 22 patients were treated with an 8 MV linear accelerator, using a 4 x 4 cm anterior direct field. The median dose was 40 Gy/20 fractions (range 28 Gy/14 fractions to 50 Gy/25 fractions). Of the 27 treatments reported, 16 resulted in a complete response (59%), six in a partial response (22%) and five resulted in no change (19%). Complete and partial responses lasted for a median time of 13 months (range of 3-89+ months). The median survival time from the start of ocular treatment was 13 months. The aim of radiation treatment is either to prevent or to postpone the visual loss caused by intraocular metastases.
1980年1月至1991年5月，我院共收治28例眼内转移瘤患者。其中3例为双侧转移，2例出现对侧受累。在33处眼转移灶中，27处接受了放射治疗。最常见的原发肿瘤部位是乳腺（18/28例患者）和肺（3/28例）。22例患者使用8兆伏直线加速器进行治疗，采用4×4厘米前向直接照射野。中位剂量为40 Gy/20次分割（范围为28 Gy/14次分割至50 Gy/25次分割）。在报告的27例治疗中，16例完全缓解（59%），6例部分缓解（22%），5例无变化（19%）。完全缓解和部分缓解的中位持续时间为13个月（范围为3 - 89 +个月）。从眼部治疗开始的中位生存时间为13个月。放射治疗的目的是预防或推迟眼内转移引起的视力丧失。
