Kanakoudi F, Drossou V, Tzimouli V, Diamanti E, Konstantinidis T, Germenis A, Kremenopoulos G
First Department of Pediatrics, Aristotle University of Thessaloniki, Greece.
Clin Chem. 1995 Apr;41(4):605-8.
Aiming to define the evolution pattern of 10 acute-phase proteins in early infancy, we measured nephelometrically the serum concentrations of albumin, prealbumin, retinol-binding protein, transferrin, ceruloplasmin, hemopexin, haptoglobin, alpha 1-acid glycoprotein, alpha 2-macroglobulin, and alpha 1-antitrypsin in 395 term and preterm infants (gestational ages 26-41 weeks). Measurements were performed within 24 h after birth and then at the end of 1 (n = 171), 3 (n = 155), and 6 (n = 90) months afterwards. Data obtained from 250 healthy adults were used as adult reference values. All proteins increased progressively with postnatal age, except for alpha 1-antitrypsin, which remained stable from birth to the 6th month. Concentrations of almost all measured proteins were significantly lower in preterm than in term infants in the first 3 months. Compared with adult values, alpha 2-macroglobulin and alpha 1-antitrypsin were higher in infants throughout the 6 months. The other proteins were significantly lower at birth than adult values but after 6 months, only albumin, prealbumin, retinol-binding protein, and alpha 1-acid glycoprotein still remained lower in infants. Thus both gestational and postnatal age should be considered when interpreting concentrations of these proteins in early infancy.
为了确定10种急性期蛋白在婴儿早期的演变模式，我们采用比浊法测量了395名足月儿和早产儿（胎龄26 - 41周）血清中白蛋白、前白蛋白、视黄醇结合蛋白、转铁蛋白、铜蓝蛋白、血红素结合蛋白、触珠蛋白、α1 - 酸性糖蛋白、α2 - 巨球蛋白和α1 - 抗胰蛋白酶的浓度。在出生后24小时内进行测量，然后在出生后1个月（n = 171）、3个月（n = 155）和6个月（n = 90）时再次测量。从250名健康成年人获得的数据用作成人参考值。除α1 - 抗胰蛋白酶从出生到6个月保持稳定外，所有蛋白质均随出生后年龄逐渐增加。在出生后的前3个月，几乎所有测量蛋白质的浓度在早产儿中均显著低于足月儿。与成人值相比，α2 - 巨球蛋白和α1 - 抗胰蛋白酶在婴儿6个月内均高于成人。其他蛋白质在出生时显著低于成人值，但在6个月后，只有白蛋白、前白蛋白、视黄醇结合蛋白和α1 - 酸性糖蛋白在婴儿中仍低于成人值。因此，在解释婴儿早期这些蛋白质的浓度时，应同时考虑胎龄和出生后年龄。
