Salemark L, Knudsen F, Dougan P
Department of Experimental Research, Malmö General Hospital, Sweden.
Br J Plast Surg. 1995 Apr;48(3):121-6. doi: 10.1016/0007-1226(95)90142-6.
Arteriotomy/intimectomy and venotomy/intimectomy were performed in the rabbit ear. Low molecular-weight dextran (dextran 40) was infused 2 h before reperfusion and on postoperative days 1, 3 and 5 using a standard clinical protocol. Bleeding-times at reperfusion were recorded and patencies determined at intervals up to 2 weeks. Rabbits given single preoperative bolus doses of saline were used as controls. Dextran significantly prolonged bleeding-times in arteries and significantly improved early patency in both types of vessel, but the enhancements disappear by one week. Dextran 40 infusion thus has little effect on long-term patency.
在兔耳上进行动脉切开术/内膜切除术和静脉切开术/内膜切除术。在再灌注前2小时以及术后第1、3和5天，按照标准临床方案输注低分子量右旋糖酐（右旋糖酐40）。记录再灌注时的出血时间，并在长达2周的时间间隔内确定通畅情况。术前单次给予生理盐水推注剂量的兔子用作对照。右旋糖酐显著延长了动脉的出血时间，并显著改善了两种血管类型的早期通畅情况，但这种改善在一周后消失。因此，输注右旋糖酐40对长期通畅情况影响不大。
