Salemark L, Knudsen F, Dougan P
Department of Plastic and Reconstructive Surgery, Malmö General Hospital, Sweden.
Microsurgery. 1995;16(2):94-7. doi: 10.1002/micr.1920160210.
Arteriotomy/intimectomy and venotomy/intimectomy were performed in the ears of 43 rabbits. Twenty were treated with iloprost given as intravenous doses of 10 micrograms/kg body weight (bw) administered shortly before reperfusion followed by hourly infusions (3 micrograms/kg b w) until 12 hrs after reperfusion. At reperfusion venous and arterial bleeding times were noted. Patency was determined at 15-min intervals until 2 hrs after reperfusion and at 1 and 2 weeks postoperatively. As controls, 23 rabbits were given a single infusion of saline. Compared to controls, iloprost significantly prolonged arterial and venous bleeding times and significantly improved patency 2 hrs after reperfusion. One and two weeks later, however, virtually all vessels were occluded. Administered in this fashion, iloprost does not improve long-term patency in highly traumatized small veins and arteries.
对43只兔子的耳朵进行动脉切开术/内膜切除术和静脉切开术/内膜切除术。20只兔子在再灌注前不久静脉注射剂量为10微克/千克体重（bw）的伊洛前列素，随后每小时输注（3微克/千克bw），直至再灌注后12小时。在再灌注时记录静脉和动脉出血时间。每隔15分钟测定一次通畅情况，直至再灌注后2小时以及术后1周和2周。作为对照，给23只兔子单次输注生理盐水。与对照组相比，伊洛前列素显著延长了动脉和静脉出血时间，并在再灌注后2小时显著改善了通畅情况。然而，1周和2周后，几乎所有血管都闭塞了。以这种方式给药，伊洛前列素并不能改善高度创伤的小静脉和动脉的长期通畅情况。
