Salemark L, Knudsen F, Dougan P
Department of Plastic and Reconstructive Surgery, University Hospital M A S, Malmö, Sweden.
J Reconstr Microsurg. 1996 May;12(4):221-6. doi: 10.1055/s-2007-1006480.
The effects of pharmacologic intervention on the fates of severely traumatized small veins and arteries have been studied in a rabbit model. Controls were given bolus doses of saline and a group treated with a combination of dextran 40 and acetylsalicylic acid starting prior to traumatization and continuing until postoperative day 5. Relative to controls, bleeding times in the treated group were significantly lengthened in arteries but not in veins, and venous patency significantly improved throughout the interval ending 2 weeks postoperatively. Arterial patency was at first highly improved but by 2 weeks, occlusion was virtually 100 percent. Since some of the occlusions took place more than a week after traumatization, the effects of antithrombotic agents on patency may need to be evaluated over considerably longer time periods than has previously been the rule.
在兔模型中研究了药物干预对严重创伤的小静脉和小动脉转归的影响。对照组给予大剂量生理盐水，一组在创伤前开始给予右旋糖酐40和乙酰水杨酸联合治疗，持续至术后第5天。与对照组相比，治疗组动脉出血时间显著延长，而静脉出血时间未延长，并且在术后2周结束的整个时间段内静脉通畅情况显著改善。动脉通畅情况起初有很大改善，但到2周时，几乎100%发生闭塞。由于一些闭塞发生在创伤后一周多，抗血栓药物对通畅情况的影响可能需要在比以往惯例长得多的时间段内进行评估。
