Torii H, Nakagawa H, Ishibashi Y
Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan.
J Dermatol. 1995 Mar;22(3):213-7. doi: 10.1111/j.1346-8138.1995.tb03374.x.
A case of so-called mixed tumor of the skin arising on the wrist was reported. Immunohistochemical staining of keratins of several molecular weights (AE1/AE3, RCK102, NCL-5D3 and 35 beta H11), carcinoembryonic antigen (CEA), S-100 protein, and desmin was performed. AE1/AE3 and RCK102 were positive in all the tumor cells; CEA, NCL-5D3 and 35 beta H11 were positive mainly in luminal cells of the tubuloalveolar structures. S-100 protein was positive in peripheral cells of the tubular lumina and in scattered cells in the mucous stroma. Desmin was negative in all the tumor cells. Immunohistochemical findings lent further support to the hypothesis that so-called mixed tumor of the skin differentiates into the secretory and ductal portions of the sweat gland.
报告了一例发生于腕部的所谓皮肤混合瘤。对多种分子量角蛋白（AE1/AE3、RCK102、NCL-5D3和35βH11）、癌胚抗原（CEA）、S-100蛋白及结蛋白进行了免疫组织化学染色。AE1/AE3和RCK102在所有肿瘤细胞中呈阳性；CEA、NCL-5D3和35βH11主要在小管腺泡结构的管腔细胞中呈阳性。S-100蛋白在肾小管腔的外周细胞及黏液基质中的散在细胞中呈阳性。结蛋白在所有肿瘤细胞中均为阴性。免疫组织化学结果进一步支持了所谓皮肤混合瘤可分化为汗腺分泌部和导管部的假说。
