感染受污染抗-D免疫球蛋白的女性将丙型肝炎病毒传播给儿童和丈夫。
Transmission of hepatitis C virus to children and husbands by women infected with contaminated anti-D immunoglobulin.
作者信息
Meisel H, Reip A, Faltus B, Lu M, Porst H, Wiese M, Roggendorf M, Krüger D H
机构信息
Institute of Medical Virology, Charité Medical School, Humboldt University, Berlin.
出版信息
Lancet. 1995 May 13;345(8959):1209-11. doi: 10.1016/s0140-6736(95)91992-9.
In 1978-79 a single-source outbreak of hepatitis C occurred in 2533 women who had received virus-contaminated anti-D immunoglobulin. Children and husbands of 74 women with self-limited, and of 86 women with chronic, hepatitis C were followed up for over 10-15 years. In 3 of 231 investigated children (1.3%) serological evidence for HCV infection was found. However, none of the children developed an apparent or chronic hepatitis. Serum samples of the 94 husbands investigated showed no HCV antibodies or HCV RNA. We consider the risk of intrauterine or perinatal transmission of HCV, as well as that of transmission through close family contacts, to be low. No evidence was found for sexual transmission for women to men.
1978 - 1979年，2533名接受了受病毒污染的抗D免疫球蛋白的女性中发生了丙型肝炎单源暴发。对74名患有自限性丙型肝炎的女性和86名患有慢性丙型肝炎的女性的子女及丈夫进行了10至15年以上的随访。在231名接受调查的儿童中有3名（1.3%）发现了丙型肝炎病毒感染的血清学证据。然而，这些儿童均未发生明显的或慢性肝炎。对94名丈夫的血清样本进行检测，未发现丙型肝炎病毒抗体或丙型肝炎病毒RNA。我们认为丙型肝炎病毒宫内或围产期传播以及通过密切家庭接触传播的风险较低。未发现女性向男性性传播的证据。
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