Bulatov A A, Kiseleva A G, Gorshkova T V, Akopova N B
Probl Endokrinol (Mosk). 1994 Nov-Dec;40(6):44-7.
A radioimmunoassay test system has been designed for measurements of free alpha-subunit (AS) of glycoprotein hormones in human blood serum with a sensitivity of 0.15 ng/ml. This test system revealed the absence of a direct correlation between the levels of free AS and levels of glycoprotein hormones in the blood sera of women with various endocrine profile, this being indicative of the specificity of this test system, on the one hand, and, on the other, confirming the possibility of independent secretion by the pituitary of free AS into the blood. Basal blood serum level of free AS in normal subjects is low: 0.9 ng/ml in women aged 17 to 30. The level of free AS secretion in the blood of many patients with nonfunctioning tumors of the pituitary was found increased, this demonstrating the diagnostic significance of measuring free AS as a marker of such tumors.
已设计出一种放射免疫分析测试系统，用于测量人血清中糖蛋白激素的游离α亚基（AS），其灵敏度为0.15 ng/ml。该测试系统显示，在具有各种内分泌特征的女性血清中，游离AS水平与糖蛋白激素水平之间不存在直接相关性，这一方面表明了该测试系统的特异性，另一方面证实了垂体将游离AS独立分泌到血液中的可能性。正常受试者血清中游离AS的基础水平较低：17至30岁女性为0.9 ng/ml。发现许多垂体无功能肿瘤患者血液中游离AS的分泌水平升高，这表明测量游离AS作为此类肿瘤标志物的诊断意义。
