酸性和碱性成纤维细胞生长因子可增强培养的大鼠脊髓神经元的轴突生长。
Acidic and basic fibroblast growth factors enhance neurite outgrowth in cultured rat spinal cord neurons.
作者信息
Iwasaki Y, Shiojima T, Ikeda K, Tagaya N, Kobayashi T, Kinoshita M
机构信息
Fourth Department of Internal Medicine, Toho University Ohashi Hospital, Tokyo, Japan.
出版信息
Neurol Res. 1995 Feb;17(1):70-2. doi: 10.1080/01616412.1995.11740289.
We have studied neurotrophic effects of acidic fibroblast growth factor (aFGF) and basic fibroblast growth factor (bFGF) on explanted ventral and dorsal spinal cord cultures from 13- and 14-day-old rat embryos. Cultures treated with aFGF and bFGF significantly enhanced neurite outgrowth with cultures of ventral spinal cord, but not with cultures of dorsal spinal cord. Our data suggest that aFGF and bFGF are potent neurotrophic factors on rat ventral spinal cord neurons in vitro.
我们研究了酸性成纤维细胞生长因子（aFGF）和碱性成纤维细胞生长因子（bFGF）对13和14日龄大鼠胚胎的腹侧和背侧脊髓外植体培养物的神经营养作用。用aFGF和bFGF处理的培养物显著增强了腹侧脊髓培养物的神经突生长，但背侧脊髓培养物则未增强。我们的数据表明，aFGF和bFGF在体外对大鼠腹侧脊髓神经元是有效的神经营养因子。
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