Iwasaki Y, Ikeda K, Shiojima T, Kobayashi T, Tagaya N, Kinoshita M
Fourth Department of Internal Medicine, Toho University Ohashi Hospital, Tokyo, Japan.
J Neurol Sci. 1994 Aug;125(1):11-3. doi: 10.1016/0022-510x(94)90235-6.
Deprenyl, a selective monoamine oxidase B inhibitor, is effective in Parkinson's disease, and can slow the cognitive deterioration in Alzheimer's disease. However, it is not known whether this agent has a trophic effect on spinal motor neurons. We have studied neurotrophic effects of deprenyl on spinal motor neurons, using explanted ventral spinal cord culture from 13-day-old rat embryos. Deprenyl-treated cultures significantly enhanced neurite outgrowth with cultures of ventral spinal cord. Our data suggest that deprenyl is one of the candidate for neurotrophic factors on spinal motor neurons in vitro. A possible role for deprenyl in amyotrophic lateral sclerosis remains to be defined.
司来吉兰是一种选择性单胺氧化酶B抑制剂，对帕金森病有效，且能减缓阿尔茨海默病的认知衰退。然而，尚不清楚该药物对脊髓运动神经元是否具有营养作用。我们利用13日龄大鼠胚胎的脊髓腹侧外植体培养物，研究了司来吉兰对脊髓运动神经元的营养作用。经司来吉兰处理的培养物显著促进了脊髓腹侧培养物的神经突生长。我们的数据表明，司来吉兰是体外脊髓运动神经元营养因子的候选物之一。司来吉兰在肌萎缩侧索硬化症中的潜在作用仍有待确定。
