Wallengren J, Badendick K, Sundler F, Håkanson R, Zander E
Department of Occupational Dermatology, Lund University.
Acta Derm Venereol. 1995 Jan;75(1):37-42. doi: 10.2340/00015555753742.
Complications of diabetes include sensory and autonomic neuropathy. The aim of the present paper was to study the degree of sensory and autonomic neuropathy and correlate these findings with the distribution and density of neuropeptidergic nerve fibers in the skin of the forearm of diabetic patients and healthy controls. We investigated 30 diabetics (24 type 1 and 6 type 2) and compared them with 13 healthy controls. There were no differences between the groups with respect to density and distribution of nerve fibers displaying immunoreactivity to the pan-neuronal marker PGP 9.5 and sensory and parasympathetic neuropeptides (substance P, calcitonin gene-related peptide and vasoactive intestinal peptide). By contrast, nerve fibers containing neuropeptide Y, a marker of sympathetic neurons, were reduced in number in the diabetic patients. C-fiber function (measured as the axon-reflex-evoked flare response) became impaired with increasing age in all subjects. The diabetic patients, however, showed a reduced flare compared to age-matched healthy controls. The reduction was particularly prominent in the younger patients (20-50 years). There was a greater reduction of the flare in neuropathic patients than in non-neuropathic patients, but there was no correlation between the degree of functional impairment and the duration of the disease.
糖尿病的并发症包括感觉神经病变和自主神经病变。本文旨在研究感觉神经病变和自主神经病变的程度，并将这些结果与糖尿病患者和健康对照者前臂皮肤中神经肽能神经纤维的分布和密度进行关联。我们调查了30名糖尿病患者（24名1型和6名2型），并将他们与13名健康对照者进行比较。在对泛神经元标记物PGP 9.5以及感觉和副交感神经肽（P物质、降钙素基因相关肽和血管活性肠肽）呈免疫反应的神经纤维的密度和分布方面，两组之间没有差异。相比之下，糖尿病患者中含有神经肽Y（交感神经元的一种标记物）的神经纤维数量减少。在所有受试者中，C纤维功能（以轴突反射诱发的光斑反应来衡量）随着年龄的增长而受损。然而，与年龄匹配的健康对照者相比，糖尿病患者的光斑反应减弱。这种减弱在较年轻的患者（20至50岁）中尤为明显。神经病变患者的光斑反应减弱程度比非神经病变患者更大，但功能损害程度与疾病持续时间之间没有相关性。
